菌種名稱: | H37Rv |
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出品公司: | ATCC |
產品編號: | 25618, ATCC25618,27294,ATCC27294 |
中文名稱: | H37Rv結核桿菌, H37Rv結核菌,H37Rv結核分枝桿菌,H37Rv結核分歧桿菌,H37Rv分枝桿菌,H37Rv分歧桿菌,H37RV肺結核菌 |
英文名稱: |
Mycobacterium tuberculosis
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培養基: | Middlebrook 7H9肉湯和ADC營養添加劑 |
生長條件: | 37℃, 有氧,這個菌生長緩慢,37度條件下,需要靜置15-20天周才能長出。 |
生物安全等級: | 3 |
分離來源: |
Derived from E.R. Baldwin's human-lung isolate H37 by W. Steenken New York, United States, 1934
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分離日期: | 1934年 |
應用: | 藥物敏感性測試,藥物研究,肺結核疾病研究。 |
是否模式菌種: | 不是 |
基因組數據: | |
參考文獻: |
Maruyama C. Immunotherapeutic agent for tumors comprising lipopolysaccharide as an active component. US Patent 4,394,502 dated Jul 19 1983
. . J. Exp. Med. 60: 515-540, 1934.
Runyon EH, et al. Mycobacterium tuberculosis, M. bovis and M. microti species descriptions. Zentralbl. Bakteriol., I Abt., Orig. 204: 405-413, 1967.
Klemens SP, et al. Therapy of multidrug-resistant tuberculosis: lessons from studies with mice. Antimicrob. Agents Chemother. 37: 2344-2347, 1993. PubMed: 8285617
Newton GL, et al. Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes. J. Bacteriol. 178: 1990-1995, 1996. PubMed: 8606174
Li Z, et al. Rapid detection of Mycobacterium avium in stool samples from AIDS patients by immunomagnetic PCR. J. Clin. Microbiol. 34: 1903-1907, 1996. PubMed: 8818878
Hackbarth CJ, et al. Cloning and sequence analysis of a class A beta-lactamase from Mycobacterium tuberculosis H37Ra. Antimicrob. Agents Chemother. 41: 1182-1185, 1997. PubMed: 9145897
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DNA序列: |
Nucleotide (GenBank) : AL123456.3 Mycobacterium tuberculosis H37Rv complete genome
Nucleotide (GenBank) : U06258 Mycobacterium tuberculosis ATCC 25618 catalase (katG) gene, complete cds.
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菌株說明: |
1. H37Rv具有A型beta內酰胺酶活性。 2. H37Rv結核桿菌的全基因組序列已經測序完成。 3. H37Rv是目前最常用的肺結核疾病研究中使用的模式菌種,被廣泛用于結核菌的科學研究。 4. H37Rv是結核分枝桿菌標準有毒株, H37Ra是從H37Rv獲得的穩定減毒株。 5. 人型結核分支桿菌H37Rv是結核病的主要病原菌, 但至今人們對其致病分子機理仍然了解甚少。 |